George Mason (2006) – The Patriots went 23-7 and earned the No. 11 seed in the Washington regional.
The run started with a victory over Michigan State and then George Mason took out North Carolina and Wichita State to set up a regional final matchup with top-seeded UConn.
George Mason outlasted Rudy Gay and Connecticut, 86-84, in overtime to become the second 11-seed in history to advance to the Final Four.